Non-vascular Guidewires are intended to be placed in the human body through a natural body orifice via endoscopes; to be guided by controllable distal and proximal ends to a certain area of the human body and to be used as a guide for catheters or any other medical devices, which are intended to be used in the certain area of the body. Those areas do not include the central circulatory system and/or the central nervous system.